Crystal Catalyst

Crystal Catalyst is an item that strengthens Spinfection (the game's poison/venom/dot effect) by increasing its damage based on the number of areas you occupy. It modifies the per-tick/per-act damage of the Spinfection effect by adding a flat amount for each area, then multiplies that value by the number of stacks (layers) of Spinfection applied to a target.

The damage increase is applied as follows: for each area you are in, Crystal Catalyst adds [EXTRA_SPINFECTION_DAMAGE_PER_ACT] to the base Spinfection damage. The resulting per-act damage is then multiplied by the current Spinfection stack count to yield the total damage dealt by the effect. Concretely, the Spinfection damage per act equals the base (10) plus the area-scaled bonus ([EXTRA_SPINFECTION_DAMAGE_PER_ACT] × number of areas), and that per-act value is multiplied by the number of Spinfection layers on the enemy.

Practical notes and interactions:

• Crystal Catalyst scales with area count, so its benefit rises when you move through or control multiple areas in a run. Positioning that increases your counted areas directly increases Spinfection damage.
• Because total damage is per-act multiplied by stacks, items or effects that increase Spinfection layers synergize strongly with Crystal Catalyst.
• Crystal Catalyst affects only the Spinfection/poison damage component; it does not change non-Spinfection damage types.
• The formula means modest per-area bonuses can become substantial with high stack counts, making this item especially valuable in builds that apply many Spinfection layers rather than relying on single high-damage hits.